Triethylamine → (2-Bromoethyl)phosphonochloridic acid

HRID 235699노트

반응식

HRID 235699 반응식
P(Cl)(Cl)(Cl)(Cl)[Cl:2].[Br:7][CH2:8][CH2:9][P:10](=[O:13])([OH:12])[OH:11].[CH2:14]([O:21][CH:22]([CH2:25][O:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH3:44])[CH2:23][OH:24])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.C(N(CC)CC)C>C(O)C.C(Cl)(Cl)Cl.C1(C)C=CC=CC=1>[Br:7][CH2:8][CH2:9][P:10]([Cl:2])(=[O:13])[OH:11].[CH2:27]([O:26][CH2:25][CH:22]([O:21][CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[CH2:23][O:24][P:10]([CH2:9][CH2:8][Br:7])(=[O:11])[O-:12])[CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH3:44]

참가 물질

9

반응물 4

HCID 8471TriethylamineHCID 24819Phosphorus pentachlorideHCID 3613627(2-Bromoethyl)phosphonic AcidHCID 131165252-(Benzyloxy)-3-(octadecyloxy)propan-1-OL

생성물 2

HCID 53742859(2-Bromoethyl)phosphonochloridic acidHCID 86741267Mono[3-(octadecyloxy)-2-(benzyloxy)propyl](2-bromoethyl)phosphonate

시약·촉매·용매 3

HCID 702Ethanol용매HCID 1140Toluene용매HCID 6212Chloroform용매

반응 조건

온도
10 °C

실험 절차

(2-Bromoethyl)phosphonic acid monochloride was prepared from phosphorous pentachloride and (2-bromoethyl)phosphonic acid according to E. Baer and N. Z. Stanacey, J. BIOL. CHEM., 10: 3754 (1965). A portion of this reagent was dissolved in about 50 ml of anhydrous, ethanol-free chloroform, cooled in an ice-water bath to about 10° C. To this was added a portion of 2-(benzyloxy)-3-(octadecyloxy)-1-propanol and about 3.0 ml of dry triethylamine in about 50 ml of dry chloroform, under argon, with stirring over a period of one hour. The reaction was allowed to stand at room temperature about 48 hours, then was refrigerated at about 0° C. overnight and then taken to dryness. The residue was dissolved in toluene, filtered and the filtrate taken to dryness. The residue was extracted with ether, giving the desired title compound as a pale yellow syrup.

후처리

  1. waitto stand at room temperature about 48 hours
  2. waitwas refrigerated at about 0° C. overnight
  3. filtrationfiltered
  4. extractionThe residue was extracted with ether

출처 및 근거

ORD 기록
ord-c4b9ec15d7b845b1a5b6298575ec4a95
출처 데이터셋
uspto-grants-1987_02
특허 번호
US04640913

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