1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride → HCID 178472544, 화합물

HRID 2356993노트

반응식

HRID 2356993 반응식
[Cl:1][C:2]1[CH:10]=[C:9]([C:11]2[NH:15][N:14]=[N:13][N:12]=2)[CH:8]=[C:7]([Cl:16])[C:3]=1[C:4]([OH:6])=O.Cl.CN(C)CCCN=C=NCC.O.ON1C2C=CC=CC=2N=N1.Cl.[CH2:41]([O:43][C:44](=[O:66])[C@@H:45]([NH2:65])[CH2:46][C:47]1[CH:52]=[CH:51][C:50]([N:53]2[C:61](=[O:62])[C:60]3[C:55](=[CH:56][CH:57]=[CH:58][C:59]=3[CH3:63])[C:54]2=[O:64])=[CH:49][CH:48]=1)[CH3:42]>ClCCl.C(N(CC)CC)C>[CH2:41]([O:43][C:44](=[O:66])[C@@H:45]([NH:65][C:4](=[O:6])[C:3]1[C:7]([Cl:16])=[CH:8][C:9]([C:11]2[NH:15][N:14]=[N:13][N:12]=2)=[CH:10][C:2]=1[Cl:1])[CH2:46][C:47]1[CH:48]=[CH:49][C:50]([N:53]2[C:61](=[O:62])[C:60]3[C:55](=[CH:56][CH:57]=[CH:58][C:59]=3[CH3:63])[C:54]2=[O:64])=[CH:51][CH:52]=1)[CH3:42]

참가 물질

7

반응물 4

HCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 27960291-Hydroxybenzotriazole hydrateHCID 66960581(2S)-2-amino-3-[4-(4-methyl-1,3-dioxo-1,3-dihydroisoindole-2-yl)phenyl]propionic acid ethylester hydrochlorideHCID 178524540HCID 178524540, 화합물

생성물 1

HCID 178472544HCID 178472544, 화합물

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 8471Triethylamine용매

실험 절차

The mixture of 35 mg of 2,6-dichloro-4-tetrazolyl benzoic acid, 30 mg of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, 23 mg of 1-hydroxybenzotriazol hydrate, 15 mg of triethylamine, 35 mg of (2S)-2-amino-3-[4-(4-methyl-1,3-dioxo-1,3-dihydroisoindole-2-yl)phenyl]propionic acid ethylester hydrochloride and 5 ml of dichloromethane was stirred at room temperature for 3 days. The mixture was concentrated and suspended in a mixed solvent of water-acetonitrile containing 0.1% trifluoroacetic acid and then filtered to obtain the title compound.

후처리

  1. concentrationThe mixture was concentrated
  2. filtrationfiltered

출처 및 근거

ORD 기록
ord-647b842b618141859aeb3f7f247b62c1
출처 데이터셋
uspto-grants-2010_07
특허 번호
US07759388B2

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