Acetic Anhydride → 4-Acetoxy-2-fluorobenzoic acid

HRID 2357

반응식

HRID 2357 반응식
[F:1][C:2]1[CH:10]=[C:9]([OH:11])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[C:12](OC(=O)C)(=[O:14])[CH3:13]>S(=O)(=O)(O)O.O>[C:12]([O:11][C:9]1[CH:8]=[CH:7][C:3]([C:4]([OH:6])=[O:5])=[C:2]([F:1])[CH:10]=1)(=[O:14])[CH3:13]

참가 물질

5

반응물 2

HCID 7918Acetic AnhydrideHCID 27833982-Fluoro-4-hydroxybenzoic Acid

생성물 1

HCID 227214164-Acetoxy-2-fluorobenzoic acid

시약·촉매·용매 2

HCID 1118Sulfuric Acid촉매HCID 962Water용매2회

반응 조건

온도
80 °C

실험 절차

4.3 Grams of 2-fluoro-4-hydroxybenzoic acid and 8.4 g of acetic anhydride were placed in a two-necked flask and mixed. While the mixture was cooled with water, 5 drops of sulfuric acid was added. After the heat generation ended, the mixture was heated at 80° C. for 30 minutes. Then, the reaction mixture was poured into cold water, and precipitated crystal was recovered by filtration. The crystal was dried under vacuum and used in a subsequent step. The yield of the crystal was 4.7 g.

후처리

  1. additionmixed
  2. additionwas added
  3. customprecipitated crystal
  4. filtrationwas recovered by filtration
  5. customThe crystal was dried under vacuum

출처 및 근거

ORD 기록
ord-83277f5bcbe3453880c179fb06727b5a
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05728864

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