Acetyl chloride → N-Acetyl-L-serine methyl ester

HRID 235710

반응식

HRID 235710 반응식
Cl.[CH3:2][O:3][C:4](=[O:9])[C@H:5]([CH2:7][OH:8])[NH2:6].C(N(CC)CC)C.[C:17](Cl)(=[O:19])[CH3:18]>C(Cl)(Cl)Cl>[C:17]([NH:6][C@H:5]([C:4]([O:3][CH3:2])=[O:9])[CH2:7][OH:8])(=[O:19])[CH3:18]

참가 물질

5

반응물 3

HCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 2723730L-Serine, methyl ester, hydrochloride (1:1)

생성물 1

HCID 7010549N-Acetyl-L-serine methyl ester

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

To a suspension of about 46.57 g of L-serine methyl ester hydrochloride in about 3 liters of chloroform was added about 84 ml of triethylamine. This mixture was stirred until solution was complete, then about 21 ml of acetyl chloride was added dropwise. The mixture was then stirred under argon for about 2 days and the chloroform removed under reduced pressure. The residue was suspended in ethanol, filtered through a sintered glass funnel and the ethanol removed, giving about 49 g of the desired title compound [α]D26 =+36°±1° (CHCl3, 1.039%).

후처리

  1. stirringThe mixture was then stirred under argon for about 2 days
  2. customthe chloroform removed under reduced pressure
  3. filtrationfiltered through a sintered glass funnel
  4. customthe ethanol removed

출처 및 근거

ORD 기록
ord-a2cbcbd39a6b4bd0989d6e6ebf5761a8
출처 데이터셋
uspto-grants-1987_02
특허 번호
US04640913

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