Cyclohexylamine → HCID 59639572, 화합물

HRID 2357298노트

반응식

HRID 2357298 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]3[CH:21]=[CH:20][C:19](=[O:22])[N:18]([C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=4[CH3:29])[C:10]=3[N:11]=[C:12](S(C)(=O)=O)[N:13]=2)=[C:4]([CH3:30])[CH:3]=1.[CH:31]1([NH2:37])[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]1>>[CH:31]1([NH:37][C:12]2[N:13]=[C:8]([C:5]3[CH:6]=[CH:7][C:2]([F:1])=[CH:3][C:4]=3[CH3:30])[C:9]3[CH:21]=[CH:20][C:19](=[O:22])[N:18]([C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=4[CH3:29])[C:10]=3[N:11]=2)[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]1

참가 물질

3

반응물 2

HCID 7965CyclohexylamineHCID 59639608HCID 59639608, 화합물

생성물 1

HCID 59639572HCID 59639572, 화합물수율 48.1%

실험 절차

Following the general procedure outlined in Example 126, the product of Example 121 (200 mg, 0.47 mmol), and cyclohexylamine (0.27 mL, 2.36 mmol) were reacted to give the crude material, which was purified as described in Example 198 to give the desired product 100 mg (48%). LC-MS: 443.4 (MH+, m/z), 2.79 (Rt, min).

후처리

  1. customto give the crude material, which
  2. customwas purified

출처 및 근거

ORD 기록
ord-b3c01bbb9dd944b5912d24f827232d57
출처 데이터셋
uspto-grants-2010_07
특허 번호
US07759486B2

반응 노트

불러오는 중…