Sodium Hydroxide → 3-(1-Isopropylphthalazin-6-yl)-4-methylbenzoic acid

HRID 2357543노트

반응식

HRID 2357543 반응식
[CH:1]([C:4]1[C:13]2[C:8](=[CH:9][C:10]([C:14]3[CH:15]=[C:16]([CH:22]=[CH:23][C:24]=3[CH3:25])[C:17]([O:19]CC)=[O:18])=[CH:11][CH:12]=2)[CH:7]=[N:6][N:5]=1)([CH3:3])[CH3:2].[OH-].[Na+]>O1CCCC1.CO>[CH:1]([C:4]1[C:13]2[C:8](=[CH:9][C:10]([C:14]3[CH:15]=[C:16]([CH:22]=[CH:23][C:24]=3[CH3:25])[C:17]([OH:19])=[O:18])=[CH:11][CH:12]=2)[CH:7]=[N:6][N:5]=1)([CH3:3])[CH3:2]

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 68455777Ethyl 3-(1-isopropylphthalazin-6-yl)-4-methylbenzoate

생성물 1

HCID 684522933-(1-Isopropylphthalazin-6-yl)-4-methylbenzoic acid

시약·촉매·용매 2

HCID 887Methanol용매HCID 8028Tetrahydrofuran용매

실험 절차

A solution of ethyl 3-(1-isopropylphthalazin-6-yl)-4-methylbenzoate (37.5 mg, 0.11 mmol) in tetrahydrofuran (0.3 mL) and methanol (0.15 mL) was treated with 1N aq. sodium hydroxide (0.28 mL, 0.28 mmol) and stirred at RT for 18 h. The reaction mixture was concentrated in vacuo and the residue was taken up in water. The pH was adjusted with 10% HCl solution to ˜7. The precipitate formed was collected via filtration and dried under high vacuum to afford the title compound as a maize-colored solid. MS (ES+): 307.2 (M+H)+.

후처리

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. customThe precipitate formed
  3. filtrationwas collected via filtration
  4. customdried under high vacuum

출처 및 근거

ORD 기록
ord-a7e68c960a7c40c980802abcf80c3f6b
출처 데이터셋
uspto-grants-2010_07
특허 번호
US07759337B2

반응 노트

불러오는 중…