P-Cresol → Sodium p-methylphenolate

HRID 2358368

반응식

HRID 2358368 반응식
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.[H-].[Na+:10]>C1COCC1>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([O-:8])=[CH:4][CH:3]=1.[Na+:10]

참가 물질

4

반응물 2

HCID 2879P-CresolHCID 24758Sodium hydride

생성물 1

HCID 23673456Sodium p-methylphenolate

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

4-methylphenol (7.45 g, 0.069 mol) is dissolved in 10 mL THF to form a solution. All of this solution then is added dropwise to a suspension of sodium hydride (1.57 g, 0.065 mol) in 40 mL THF to form a sodium 4-methylphenoxide solution. All of the sodium 4-methylphenoxide solution then is added to the polymeric solution in the autoclave. The autoclave is sealed and heated to 150° C. to generate a pressure of 3.5 bar. After 30 hours, the autoclave is cooled to room temperature and the resulting product of substituted polymer in solution is concentrated via rotary evaporation by using the Buchi Rotavapor as described above, until viscous. Then, all of the viscous polymer solution is precipitated into 6 M aqueous HCl and the polymer precipitate allowed to air dry in a fume hood.

후처리

  1. customto form a solution

출처 및 근거

ORD 기록
ord-eb1a1f8d769c468c915bef0951b0c6d4
출처 데이터셋
uspto-grants-2010_07
특허 번호
US07763702B2

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