2-(Trifluoromethyl)aniline → 4-Iodo-2-(trifluoromethyl)aniline

HRID 2358385노트

반응식

HRID 2358385 반응식
[F:1][C:2]([F:11])([F:10])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[NH2:9].[I:12]Cl>C(Cl)Cl>[I:12][C:7]1[CH:6]=[CH:5][C:4]([NH2:9])=[C:3]([C:2]([F:10])([F:11])[F:1])[CH:8]=1

참가 물질

4

반응물 2

HCID 69222-(Trifluoromethyl)anilineHCID 24640Iodine chloride

생성물 1

HCID 32894324-Iodo-2-(trifluoromethyl)aniline수율 42.5%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

2-Trifluoromethylphenylamine (30 mg, 0.21 mmol) and ICl (1.1 eq, 0.24 mmol, 38.97 mg) were added into methylene chloride. The reaction mixture was stirred for 12 hr. The reaction mixture was purified according to step 2 of Example 8 to give a title compound (25.6 mg, 42.48%).

후처리

  1. customThe reaction mixture was purified

출처 및 근거

ORD 기록
ord-88b17524ca914712b38405136e8f2f3f
출처 데이터셋
uspto-grants-2010_07
특허 번호
US07763657B2

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