Dimethylformamide → 4-Amino-3-(trifluoromethyl)benzonitrile

HRID 2358386노트

반응식

HRID 2358386 반응식
I[C:2]1[CH:7]=[CH:6][C:5]([NH2:8])=[C:4]([C:9]([F:12])([F:11])[F:10])[CH:3]=1.[CH3:13][N:14](C=O)C>[C-]#N.[C-]#N.[Zn+2].C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[NH2:8][C:5]1[CH:6]=[CH:7][C:2]([C:13]#[N:14])=[CH:3][C:4]=1[C:9]([F:12])([F:11])[F:10]

참가 물질

5

반응물 2

HCID 6228DimethylformamideHCID 32894324-Iodo-2-(trifluoromethyl)aniline

생성물 1

HCID 27794884-Amino-3-(trifluoromethyl)benzonitrile수율 99.28%

시약·촉매·용매 2

HCID 11186Zinc cyanide (Zn(CN)2)촉매2회HCID 178418397HCID 178418397, 화합물촉매2회

실험 절차

4-Iodo-2-trifluoromethylphenylamine (50 mg, 0.17 mmol), Zn(CN)2 (0.88 eq, 0.15 mmol, 18.00 mg), and Pd(PPh3)4 (0.1 eq, 0.02 mmol, 19.64 mg) were added in DMF. Zn(CN)2 (0.88 eq, 0.15 mmol, 18.00 mg) and Pd(PPh3)4 (0.1 eq, 0.02 mmol, 19.64 mg) were added into the reaction mixture. The reaction mixture was stirred for 12 hr. The reaction mixture was purified according to step 1 of Example 8 to give a title product as a yellow solid (31.4 mg, 99.28%).

후처리

  1. customThe reaction mixture was purified

출처 및 근거

ORD 기록
ord-6b2ad0d85656467c995735799c585ae7
출처 데이터셋
uspto-grants-2010_07
특허 번호
US07763657B2

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