Phosphorus oxychloride → 5-Chloro-2-propyl-[1,8]naphthyridine

HRID 2358536노트

반응식

HRID 2358536 반응식
[CH2:1]([C:4]1[N:13]=[C:12]2[C:7]([C:8](O)=[CH:9][CH:10]=[N:11]2)=[CH:6][CH:5]=1)[CH2:2][CH3:3].O=P(Cl)(Cl)[Cl:17]>>[Cl:17][C:8]1[CH:9]=[CH:10][N:11]=[C:12]2[C:7]=1[CH:6]=[CH:5][C:4]([CH2:1][CH2:2][CH3:3])=[N:13]2

참가 물질

3

반응물 2

HCID 24813Phosphorus oxychlorideHCID 178438802HCID 178438802, 화합물

생성물 1

HCID 441401765-Chloro-2-propyl-[1,8]naphthyridine수율 86%

실험 절차

The product from Example 2f (145 mg, 0.76 mmol) was reacted with POCl3 4 mL following the procedure from Example 1d giving the title compound as a solid (135 mg, 86%).

출처 및 근거

ORD 기록
ord-52c2ca48a21547a0aad6bfe0b6a3c6a3
출처 데이터셋
uspto-grants-2010_07
특허 번호
US07763731B2

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