Phosphorus oxychloride → 5-Chloro-2-ethyl-1,8-naphthyridine

HRID 2358543노트

반응식

[CH2:1]([C:3]1[N:12]=[C:11]2[C:6]([C:7](O)=[CH:8][CH:9]=[N:10]2)=[CH:5][CH:4]=1)[CH3:2].O=P(Cl)(Cl)[Cl:16]>>[Cl:16][C:7]1[CH:8]=[CH:9][N:10]=[C:11]2[C:6]=1[CH:5]=[CH:4][C:3]([CH2:1][CH3:2])=[N:12]2

참가 물질

반응물 2

HCID 24813Phosphorus oxychloride

HCID 178435554HCID 178435554, 화합물

생성물 1

HCID 672512035-Chloro-2-ethyl-1,8-naphthyridine수율 83%

실험 절차

The product from Example 3e (200 mg, 1.14 mmol) was treated with POCl3 following the procedure from Example 1d giving the title compound as a brown solid (183 mg, 83%).

출처 및 근거

ORD 기록: ord-b378632bf7dc4f7cb9e31480bc0c5d4b
출처 데이터셋: uspto-grants-2010_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07763731B2

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