Ethyl bromoacetate → HCID 13773131, 화합물

HRID 235891노트

반응식

HRID 235891 반응식
[Cl:1][C:2]1[CH:18]=[CH:17][C:5]([C:6]([NH:8][CH2:9][C:10]([C:12]2[CH:16]=[CH:15][O:14][CH:13]=2)=[O:11])=[O:7])=[CH:4][CH:3]=1.[H-].[Na+].Br[CH2:22][C:23]([O:25][CH2:26][CH3:27])=[O:24]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([NH:8][CH:9]([C:10]([C:12]2[CH:16]=[CH:15][O:14][CH:13]=2)=[O:11])[CH2:22][C:23]([O:25][CH2:26][CH3:27])=[O:24])=[O:7])=[CH:17][CH:18]=1

참가 물질

4

반응물 3

HCID 7748Ethyl bromoacetateHCID 24758Sodium hydrideHCID 137731224-Chloro-N-[2-(furan-3-yl)-2-oxoethyl]benzamide

생성물 1

HCID 13773131HCID 13773131, 화합물수율 77.3%

실험 절차

8.3 g of N-(4-chlorobenzoyl)-(3-furylcarbonyl)methylamine, 1.5 g of 61% sodium hydride and 5.8 g of ethyl bromoacetate are treated in the same manner as described in Preparation 1-(2). 8.5 g of ethyl 3-(4-chlorobenzoylamino)-3-(3-furylcarbonyl)propionate are thereby obtained. Yield: 77.3%

후처리

  1. customas described in Preparation 1-(2)

출처 및 근거

ORD 기록
ord-df81bac86a9f487f9cf97540113d17b7
출처 데이터셋
uspto-grants-1987_02
특허 번호
US04642313

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