Ethyl bromoacetate → Ethyl 3-acetylamino-3-(2-furylcarbonyl)propionate

HRID 235900노트

반응식

HRID 235900 반응식
[C:1]([NH:4][CH2:5][C:6]([C:8]1[O:9][CH:10]=[CH:11][CH:12]=1)=[O:7])(=[O:3])[CH3:2].[H-].[Na+].Br[CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18]>>[C:1]([NH:4][CH:5]([C:6]([C:8]1[O:9][CH:10]=[CH:11][CH:12]=1)=[O:7])[CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18])(=[O:3])[CH3:2]

참가 물질

4

반응물 3

HCID 7748Ethyl bromoacetateHCID 24758Sodium hydrideHCID 13773126N-[2-(Furan-2-yl)-2-oxoethyl]acetamide

생성물 1

HCID 13773136Ethyl 3-acetylamino-3-(2-furylcarbonyl)propionate수율 41%

실험 절차

2.6 g of N-acetyl-(2-furylcarbonyl)methylamine, 0.74 g of 61% sodium hydride and 2.9 g of ethyl bromoacetate are treated in the same manner as described in Preparation 1-(2). 1.6 g of ethyl 3-acetylamino-3-(2-furylcarbonyl)propionate are thereby obtained. Yield: 41%

후처리

  1. customas described in Preparation 1-(2)

출처 및 근거

ORD 기록
ord-cf7a9daec9664351b0543f3116ef2ab9
출처 데이터셋
uspto-grants-1987_02
특허 번호
US04642313

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