Benzylamine → HCID 67261084, 화합물

HRID 2359042노트

반응식

HRID 2359042 반응식
[Cl:1][C:2]1[S:6][C:5]([C:7]2[C:11]([C:12]3[CH:17]=[CH:16][N:15]=[C:14](S(C)(=O)=O)[N:13]=3)=[CH:10][N:9]([CH:22]([CH3:24])[CH3:23])[N:8]=2)=[CH:4][CH:3]=1.[CH2:25]([NH2:32])[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1>>[CH2:25]([NH:32][C:14]1[N:13]=[C:12]([C:11]2[C:7]([C:5]3[S:6][C:2]([Cl:1])=[CH:3][CH:4]=3)=[N:8][N:9]([CH:22]([CH3:24])[CH3:23])[CH:10]=2)[CH:17]=[CH:16][N:15]=1)[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1

참가 물질

3

반응물 2

HCID 7504BenzylamineHCID 67260704HCID 67260704, 화합물

생성물 1

HCID 67261084HCID 67261084, 화합물수율 96%

실험 절차

A mixture of 4-[3-(5-chloro-2-thienyl)-1-isopropyl-1H-pyrazol-4-yl]-2-(methylsulfonyl)pyrimidine (1 eq, 5.2 mmol) in 25 mL benzylamine was stirred overnight at room temperature. The solvent was evaporated and the residue was diluted in dichloromethane and washed three times with HCl 1M. The organic layer was then dried over MgSO4 and evaporated to afford 2.3 g of N-benzyl-4-[3-(5-chloro-2-thienyl)-1-isopropyl-1H-pyrazol-4-yl]pyrimidin-2-amine (96% yield).

후처리

  1. customThe solvent was evaporated
  2. additionthe residue was diluted in dichloromethane
  3. washwashed three times with HCl 1M
  4. dry with materialThe organic layer was then dried over MgSO4
  5. customevaporated

출처 및 근거

ORD 기록
ord-69a9e99851844966ba2b881130057480
출처 데이터셋
uspto-grants-2014_04
특허 번호
US08685974B2

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