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2-Pyrazinecarboxylic acid → HCID 44251588, 화합물

HRID 2359388
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HRID 2359388 반응식
[C:1]1([C:7]2[CH:16]=[CH:15][C:14]3[C:9](=[C:10]([NH2:17])[CH:11]=[CH:12][CH:13]=3)[N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[N:18]1[CH:23]=[CH:22][N:21]=[CH:20][C:19]=1[C:24](O)=[O:25].CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.CCN(C(C)C)C(C)C>CN(C=O)C.CCOC(C)=O>[C:1]1([C:7]2[CH:16]=[CH:15][C:14]3[C:9](=[C:10]([NH:17][C:24]([C:19]4[CH:20]=[N:21][CH:22]=[CH:23][N:18]=4)=[O:25])[CH:11]=[CH:12][CH:13]=3)[N:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

7

반응물 4

HCID 10472-Pyrazinecarboxylic acidHCID 81531DiisopropylethylamineHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 199558612-Phenylquinolin-8-amine

생성물 1

HCID 44251588HCID 44251588, 화합물수율 11.3%

시약·촉매·용매 2

HCID 6228Dimethylformamide용매
HCID 8857Ethyl Acetate용매

실험 절차

2-Phenylquinolin-8-amine (60 mg, 0.27 mmol) was taken up in 2 mL of DMF along with pyrazine-2-carboxylic acid (34 mg, 0.27 mmol), HATU (207 mg, 0.54 mmol) and DIEA (95 μL, 0.54 mmol). The reaction mixture was stirred at room temperature for 18 h. It was then diluted with EtOAc and washed with water. The organic layer was dried (Na2SO4) and concentrated under reduced pressure. The resulting residue was purified by preparative HPLC (using aqueous CH3CN that has been buffered with 0.1% TFA) to afford 10 mg of the product. MS (ESI) calcd for C20H14N4O (m/z): 326.12. found: 327 [M+1].

후처리

  1. washwashed with water
  2. dry with materialThe organic layer was dried (Na2SO4)
  3. concentrationconcentrated under reduced pressure
  4. customThe resulting residue was purified by preparative HPLC (using aqueous CH3CN that has been buffered with 0.1% TFA)

출처 및 근거

ORD 기록
ord-0dbe8934bb77407fbf01b0aaefe415e3
출처 데이터셋
uspto-grants-2014_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08685970B2

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