Sodium Carbonate → 4-methoxy-3-methylbenzonitrile

HRID 235950노트

반응식

HRID 235950 반응식
[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:6]([CH:7]=[N:8]O)=[CH:5][C:4]=1[CH3:12].C([O-])([O-])=O.[Na+].[Na+]>C(OC(=O)C)(=O)C>[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]#[N:8])=[CH:5][C:4]=1[CH3:12]

참가 물질

4

반응물 2

HCID 10340Sodium CarbonateHCID 42375924-Methoxy-3-methylbenzaldoxime

생성물 1

HCID 136216134-methoxy-3-methylbenzonitrile

시약·촉매·용매 1

HCID 7918Acetic Anhydride용매

실험 절차

A solution of 20 (30.9 g, 0.187 mole) in of acetic anhydride (200 ml) heated at reflux for 1.5 hours, cooled to room temperature and poured with vigorous stirring into 2N aqueous Na2CO3 (2 L). Overnight refrigeration gave a solid which was collected, washed with water, and dried to give 25.6 grams (93%) of 21 m.p. 48°-50°.

후처리

  1. temperatureat reflux for 1.5 hours
  2. additionpoured
  3. customOvernight refrigeration gave a solid which
  4. customwas collected
  5. washwashed with water
  6. customdried
  7. customto give 25.6 grams (93%) of 21 m
  8. custom48°-50°

출처 및 근거

ORD 기록
ord-1f39a2408f034349a2819aa25e755bed
출처 데이터셋
uspto-grants-1987_02
특허 번호
US04642311

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