Water → 2-[4-(4-Bromo-2-fluorophenoxy)phenoxy]propionic acid methyl ester

HRID 235980노트

반응식

HRID 235980 반응식
[Br:1][C:2]1[CH:15]=[CH:14][C:5]([O:6][C:7]2[CH:12]=[CH:11][C:10]([OH:13])=[CH:9][CH:8]=2)=[C:4]([F:16])[CH:3]=1.Br[CH:18]([CH3:23])[C:19]([O:21][CH3:22])=[O:20].C(=O)([O-])[O-].[K+].[K+].O>CS(C)=O>[CH3:22][O:21][C:19](=[O:20])[CH:18]([O:13][C:10]1[CH:9]=[CH:8][C:7]([O:6][C:5]2[CH:14]=[CH:15][C:2]([Br:1])=[CH:3][C:4]=2[F:16])=[CH:12][CH:11]=1)[CH3:23]

참가 물질

6

반응물 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 95576Methyl 2-bromopropionateHCID 135337314-(4-Bromo-2-fluorophenoxy)phenol

생성물 1

HCID 135337252-[4-(4-Bromo-2-fluorophenoxy)phenoxy]propionic acid methyl ester

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

실험 절차

A mixture of the 4-(4-bromo-2-fluorophenoxy)phenol (5.66 g, 0.02 mol) from Step V, methyl 2-bromoproprionate (3.34 g, 0.02 mol) and potassium carbonate (3.06 g, 0.22 mol) in DMSO (30 ml) was stirred, under an atmosphere of nitrogen, at room temperature for 18 hours. The mixture was poured into water (300 ml), and the resulting mixture extracted with ether (2×100 ml). The ether extracts were combined, washed with water (100 ml), dried (MgSO4), and the solvent evaporated to give the desired 2-[4-(4-bromo-2-fluorophenoxy)phenoxy]propionic acid; methyl ester as a yellow oil (6.0 g, 81%); RI=1.5628; NMR (CDCl3) was consistent with the assigned structure. The carbon and hydrogen content was as follows:

후처리

  1. extractionthe resulting mixture extracted with ether (2×100 ml)
  2. washwashed with water (100 ml)
  3. dry with materialdried (MgSO4)
  4. customthe solvent evaporated

출처 및 근거

ORD 기록
ord-e43ff8a1c57c44268c15b9bd14d17993
출처 데이터셋
uspto-grants-1987_02
특허 번호
US04642338

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