Cyclohexyl isocyanate → N-(cyclohexyl)-N'-(2-chloroethyl)imidazolidinone

HRID 235990

반응식

HRID 235990 반응식
[CH:1]1([N:7]=[C:8]=[O:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[Cl:10][CH2:11][CH2:12][N:13]1[CH2:17][CH2:16]OC1=O.[Al+3].[Cl-].[Cl-].[Cl-]>ClCCl>[CH:1]1([N:7]2[CH2:16][CH2:17][N:13]([CH2:12][CH2:11][Cl:10])[C:8]2=[O:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

5

반응물 3

HCID 18502Cyclohexyl isocyanateHCID 756333-(2-Chloroethyl)-1,3-oxazolidin-2-oneHCID 6451240Aluminum(III) Chloride

생성물 1

HCID 13824504N-(cyclohexyl)-N'-(2-chloroethyl)imidazolidinone수율 50%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
195 °C

실험 절차

A mixture of cyclohexyl isocyanate (50 mmoles), N-(2-chloroethyl)-2-oxazolidinone (50 mmoles) and anhydrous AlCl3 (40 mg, 0.3 mmole) is heated at 195° C. for 6 hours with stirring. The reaction mixture is dissolved in dichloromethane and the resulting solution is washed with water twice. The dichloromethane solution is dried and evaporated and the residue distilled at reduced pressure. The distillate is recrystallized from hot hexane to give a 50 percent yield of the desired product, m.p. 60° C.-64° C.

후처리

  1. washthe resulting solution is washed with water twice
  2. dry with materialThe dichloromethane solution is dried
  3. customevaporated
  4. distillationthe residue distilled at reduced pressure
  5. customThe distillate is recrystallized from hot hexane

출처 및 근거

ORD 기록
ord-f87341538a644f02b389ec24f511ea04
출처 데이터셋
uspto-grants-1987_02
특허 번호
US04642351

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