Benzene, 1-chloro-3-isocyanato- → 1-(3-Chlorophenyl)imidazolidin-2-one
반응식
[Cl:1][C:2]1[CH:3]=[C:4]([N:8]=[C:9]=[O:10])[CH:5]=[CH:6][CH:7]=1.O1[CH2:15][CH2:14][NH:13]C1=O.[Al+3].[Cl-].[Cl-].[Cl-]>ClCCl>[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[CH2:15][CH2:14][NH:13][C:9]2=[O:10])[CH:5]=[CH:6][CH:7]=1참가 물질
5
반응 조건
- 온도
- 195 °C
실험 절차
A mixture of 3-chlorophenyl isocyanate (50 mmoles), 2-oxazolidinone (50 mmoles) and anhydrous AlCl3 (40 mg, 0.3 mmole) is heated at 195° C. for 6 hours with stirring. The reaction mixture is dissolved in dichloromethane and the resulting solution is washed with water twice. The dichloromethane solution is dried and evaporated and the residue distilled at reduced pressure. The distillate is recrystallized from hot hexane to give a yield of 74 percent of the desired product, m.p. 121° C.-123° C.
후처리
- washthe resulting solution is washed with water twice
- dry with materialThe dichloromethane solution is dried
- customevaporated
- distillationthe residue distilled at reduced pressure
- customThe distillate is recrystallized from hot hexane
출처 및 근거
- ORD 기록
- ord-49e9d5a146a249c7b0465e8d85ac2964
- 출처 데이터셋
- uspto-grants-1987_02
- 특허 번호
- US04642351
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