Diethanolamine → HCID 22590162, 화합물

HRID 23612

반응식

HRID 23612 반응식
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][C:10]=1F)[C:6]#[N:7].[NH:14]([CH2:18][CH2:19][OH:20])[CH2:15][CH2:16][OH:17]>CN(C)C(=O)C>[F:1][C:2]([F:13])([F:12])[C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][C:10]=1[N:14]([CH2:18][CH2:19][OH:20])[CH2:15][CH2:16][OH:17])[C:6]#[N:7]

참가 물질

4

반응물 2

HCID 8113DiethanolamineHCID 1442554-Fluoro-3-(trifluoromethyl)benzonitrile

생성물 1

HCID 22590162HCID 22590162, 화합물

시약·촉매·용매 1

HCID 31374Dimethylacetamide용매

실험 절차

A solution of 3-trifluoromethyl 4-fluoro-benzonitrile (9.45 g, 50 mmol) and diethanolamine (15.8 g, 0.15 mol) in N,N-dimethylacetamide (200 ml) was stirred for 7 days at 50° C. The solvent was evaporated, the residue partitioned between CH2Cl2 (400 ml) and H2O (400 ml), the organic layer dried (MgSO4) and evaporated to dryness. The residue was chromatographed using CH2Cl2-EtOH as eluent.

후처리

  1. customThe solvent was evaporated
  2. customthe residue partitioned between CH2Cl2 (400 ml) and H2O (400 ml)
  3. dry with materialthe organic layer dried (MgSO4)
  4. customevaporated to dryness
  5. customThe residue was chromatographed

출처 및 근거

ORD 기록
ord-02ab42cfd43b416bbf1faed23df2983f
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06852755B1

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