Sodium Hydroxide → HCID 178516346, 화합물
반응식
[OH-:1].[Na+].ClC(Cl)(Cl)[C:5]1[CH:10]=[CH:9][N:8]2[C:11]3[CH:17]=[CH:16][CH:15]=[CH:14][C:12]=3[N:13]=[C:7]2[N:6]=1>C(#N)C>[N:6]1[C:7]2[N:8]([C:11]3[CH:17]=[CH:16][CH:15]=[CH:14][C:12]=3[N:13]=2)[CH:9]=[CH:10][C:5]=1[OH:1]참가 물질
4
실험 절차
Sodium hydroxide (36.5 ml, 36.5 mmol) was added to a solution containing 2-(trichloromethyl)-benzo[4,5]imidazo[1,2-a]pyrimidine (8.04 g, 28.1 mmol) in Acetonitrile (Volume: 122 ml). Heated the reaction to 90 C for 30 minutes. Cooled the reaction to room temperature and concentrated. Added ice to the resulting residue, followed by 35 mL of 1M HCl. Filtered the solid and dried under vacuum to afford crude benzo[4,5]imidazo[1,2-a]pyrimidin-2-ol (5.2 g, 28.1 mmol, 100% yield).
후처리
- temperatureHeated
- customthe reaction to 90 C for 30 minutes
- temperatureCooled
- customthe reaction to room temperature
- concentrationconcentrated
- filtrationFiltered the solid
- customdried under vacuum
출처 및 근거
- ORD 기록
- ord-20435265506d481984f80f3594002810
- 출처 데이터셋
- uspto-grants-2014_04
- 특허 번호
- US08691187B2
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