Acetic Anhydride → HCID 12896718, 화합물

HRID 2361627노트

반응식

HRID 2361627 반응식
[C@@H:1]1([N:10]2[CH:15]=[CH:14][C:13](=[O:16])[NH:12][C:11]2=[O:17])[O:7][C@H:6]([CH2:8][OH:9])[C@@H:4]([OH:5])[C@@H:2]1[OH:3].C(O[C:22](=[O:24])[CH3:23])(=O)C>N1C=CC=CC=1>[C:2]([O:3][C@H:2]1[C@H:4]([O:5][C:4](=[O:5])[CH3:6])[C@@H:6]([CH2:8][O:9][C:22](=[O:24])[CH3:23])[O:7][C@H:1]1[N:10]1[CH:15]=[CH:14][C:13](=[O:16])[NH:12][C:11]1=[O:17])(=[O:3])[CH3:1]

참가 물질

4

반응물 2

HCID 7918Acetic AnhydrideHCID 18323Uracil Arabinoside

생성물 1

HCID 12896718HCID 12896718, 화합물

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

500 mg (2.05 mmol) of the above product 3 is taken as the starting material, and dissolved in 35 mL of pyridine. Then 11 ml of acetic anhydride is added with continuously stirring. The solution is concentrated under reduced pressure by removing the residual part of the solution after the completion of the reaction, and then purified by rapid column chromatography (acetone/n-hexane=4:5). A white product (1-(2′,3′,5′-Tri-O-acetyl-β-D-arabinofuranosyl)-pyrimidin-2,4-(3H)-dione) 4 is obtained. Its weight and yield are 675 mg and 89% respectively.

후처리

  1. concentrationThe solution is concentrated under reduced pressure
  2. customby removing the residual part of the solution
  3. customafter the completion of the reaction
  4. custompurified by rapid column chromatography (acetone/n-hexane=4:5)

출처 및 근거

ORD 기록
ord-19a103e640fc4e2f93ba7714bc8c86ab
출처 데이터셋
uspto-grants-2014_04
특허 번호
US08691789B2

반응 노트

불러오는 중…