Hydrochloric Acid → Hydrochloric Acid

HRID 2361708노트

반응식

HRID 2361708 반응식
[O:1]=[C:2]1[CH:9]2[CH2:10][C:5]3([NH:12]C(=O)C)[CH2:6][CH:7]([CH2:11][CH:3]1[CH2:4]3)[CH2:8]2.[ClH:16]>>[NH2:12][C:5]12[CH2:10][CH:9]3[CH2:8][CH:7]([CH2:11][CH:3]([C:2]3=[O:1])[CH2:4]1)[CH2:6]2.[ClH:16]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 5338964N-(4-oxo-1-adamantyl)acetamide

생성물 2

HCID 313Hydrochloric AcidHCID 528351HCID 528351, 화합물

실험 절차

A solution of N-(4-oxoadamantan-1-yl)acetamide (1A) (20 mmol) in 200 mL of concentrated, aqueous HCl was heated in a sealed pressure tube at 130° C. for 20 h. The solvent was removed under reduced pressure to give amine 1B as an HCl salt in 90% yield as an off-white solid. Data: LC/MS (ESR) m/z 166 [M+1]+.

후처리

  1. customThe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-a2510aca39bb4a17a42d33a8c433a65f
출처 데이터셋
uspto-grants-2014_04
특허 번호
US08691808B2

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