Dimethylformamide dimethyl acetal → HCID 66719111, 화합물

HRID 2362149노트

반응식

HRID 2362149 반응식
[C:1]([O:5][C:6](=[O:27])[NH:7][C:8]1([C:12]2[CH:17]=[CH:16][C:15]([C:18](=[O:26])[CH2:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[CH:14][CH:13]=2)[CH2:11][CH2:10][CH2:9]1)([CH3:4])([CH3:3])[CH3:2].[CH3:28][N:29]([CH:31](OC)OC)[CH3:30]>C1(C)C=CC=CC=1>[C:1]([O:5][C:6](=[O:27])[NH:7][C:8]1([C:12]2[CH:13]=[CH:14][C:15]([C:18](=[O:26])[C:19]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[CH:28][N:29]([CH3:31])[CH3:30])=[CH:16][CH:17]=2)[CH2:11][CH2:10][CH2:9]1)([CH3:4])([CH3:2])[CH3:3]

참가 물질

4

반응물 2

HCID 78373Dimethylformamide dimethyl acetalHCID 57805516tert-Butyl {1-[4-(phenylacetyl)phenyl]cyclobutyl}carbamate

생성물 1

HCID 66719111HCID 66719111, 화합물

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

To a solution of compound 1-3 (5.0 g, 13.7 mmol) in toluene (30 mL) was added DMFDMA (18.15 g, 68.4 mmol) and the mixture was heated at reflux for 4 hours. The TLC showed the starting material was disappeared. The mixture was cooled and the formed white solid was collected. After washed by PE, the solid was dried in vacuum to get the product 1.

후처리

  1. temperaturethe mixture was heated
  2. temperatureat reflux for 4 hours
  3. temperatureThe mixture was cooled
  4. customthe formed white solid was collected
  5. washAfter washed by PE
  6. customthe solid was dried in vacuum

출처 및 근거

ORD 기록
ord-8c6d2d1f2ffe48f480172971da07ad95
출처 데이터셋
uspto-grants-2014_04
특허 번호
US08691825B2

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