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Hydrogen Peroxide → 7-[4-(1-Amino-cyclobutyl)-phenyl]-6-phenyl-imidazo[1,2-a]pyrimidine-3-carboxylic Acid Amide

HRID 2362165
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HRID 2362165 반응식
[NH2:1][C:2]1([C:6]2[CH:11]=[CH:10][C:9]([C:12]3[C:17]([C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=4)=[CH:16][N:15]4[C:24]([C:27]#[N:28])=[CH:25][N:26]=[C:14]4[N:13]=3)=[CH:8][CH:7]=2)[CH2:5][CH2:4][CH2:3]1.[OH:29]O>CS(C)=O.CC(=O)OCC>[NH2:1][C:2]1([C:6]2[CH:7]=[CH:8][C:9]([C:12]3[C:17]([C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=4)=[CH:16][N:15]4[C:24]([C:27]([NH2:28])=[O:29])=[CH:25][N:26]=[C:14]4[N:13]=3)=[CH:10][CH:11]=2)[CH2:5][CH2:4][CH2:3]1
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참가 물질

5

반응물 2

HCID 784Hydrogen PeroxideHCID 469271627-[4-(1-Amino-cyclobutyl)-phenyl]-6-phenyl-imidazo[1,2-a]pyrimidine-3-carbonitrile

생성물 1

HCID 469271637-[4-(1-Amino-cyclobutyl)-phenyl]-6-phenyl-imidazo[1,2-a]pyrimidine-3-carboxylic Acid Amide

시약·촉매·용매 2

HCID 679Dimethyl Sulfoxide용매HCID 8857Ethyl Acetate용매

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온도
60 °C

실험 절차

To a suspension of compound 4-10 (40 mg 0.11 mmol.) and K2 CO3 (30 mg, 0.22 mmol) in DMSO (1.0 mL) was added 0.1 mL of H2O2(30% aq.) and the mixture was heated at 60° C. for 3 h. After cooling, the mixture was diluted with 20 mL of EA, the combined organic phase was washed with sat.NaHSO3 (aq) and brine, dried over anhydrous Na2SO4 and concentrated. The residue was purified by prep.HPLC to give 19 mg of 4-11.

후처리

  1. temperatureAfter cooling
  2. washthe combined organic phase was washed
  3. dry with materialNaHSO3 (aq) and brine, dried over anhydrous Na2SO4
  4. concentrationconcentrated
  5. customThe residue was purified by prep.HPLC

출처 및 근거

ORD 기록
ord-fa79ef82a6514ce785de077cf6585e0a
출처 데이터셋
uspto-grants-2014_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08691825B2

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