Ethyl orthoformate → HCID 22320486, 화합물

HRID 2362503노트

반응식

HRID 2362503 반응식
[Si:1]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][NH:13][C:14]1[C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[N:17]=[CH:16][C:15]=1[NH2:24])([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].[CH:25](OCC)(OCC)OCC>C1(C)C=CC=CC=1>[Si:1]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][N:13]1[C:14]2[C:23]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[N:17]=[CH:16][C:15]=2[N:24]=[CH:25]1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2]

참가 물질

4

반응물 2

HCID 31214Ethyl orthoformateHCID 12106183HCID 12106183, 화합물

생성물 1

HCID 22320486HCID 22320486, 화합물

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A mixture of N4-[4-(tert-butyldimethylsilanyloxy)butyl]quinoline-3,4-diamine (101 g, 293 mmol) and triethyl orthoformate (43.4 g, 293 mmol) in toluene (200 mL) was heated at reflux for 2 hours and then concentrated under reduced pressure to provide 1-[4-(tert-butyldimethylsilanyloxy)butyl]-1H-imidazo[4,5-c]quinoline as an oil that was used directly in the next step without further purification.

후처리

  1. temperaturewas heated
  2. temperatureat reflux for 2 hours
  3. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-a2936a36f68d4f22ba7963b71cc597f1
출처 데이터셋
uspto-grants-2014_04
특허 번호
US08691837B2

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