Lithium hydroxide, monohydrate → Lithium 1-(2-chloro-benzenesulfonyl)-piperidine-3-carboxylate

HRID 2362776노트

반응식

HRID 2362776 반응식
C([O:3][C:4]([CH:6]1[CH2:11][CH2:10][CH2:9][N:8]([S:12]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[Cl:21])(=[O:14])=[O:13])[CH2:7]1)=[O:5])C.O[Li:23].O>C1COCC1.CO.O>[Cl:21][C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=1[S:12]([N:8]1[CH2:9][CH2:10][CH2:11][CH:6]([C:4]([O-:5])=[O:3])[CH2:7]1)(=[O:13])=[O:14].[Li+:23]

참가 물질

4

반응물 2

HCID 168937Lithium hydroxide, monohydrateHCID 38620101-(2-Chloro-benzenesulfonyl)-piperidine-3-carboxylic acid ethyl ester

생성물 1

HCID 67131265Lithium 1-(2-chloro-benzenesulfonyl)-piperidine-3-carboxylate

시약·촉매·용매 1

HCID 21892291Methanol tetrahydrofuran water용매

실험 절차

To a solution of 5.7 g 1-(2-chloro-benzenesulfonyl)-piperidine-3-carboxylic acid ethyl ester (17 mmol) in 30 mL THF: methanol:water (2:1:1) was added 1.08 g LiOH H2O (25.7 mmol). The mixture was stirred at room temperature for 5-6 h and all volatiles were evaporated to dryness. The compound was used in the consecutive step without further purification.

후처리

  1. customall volatiles were evaporated to dryness
  2. customThe compound was used in the consecutive step without further purification

출처 및 근거

ORD 기록
ord-79f7c542e757489bbeaf0e7b8d53ac26
출처 데이터셋
uspto-grants-2014_04
특허 번호
US08691846B2

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