Hydrochloric Acid → 6-Amino-1-cyclopropyl-5-nitroso-2,4(1H,3H)-pyrimidinedione
반응식
[NH2:1][C:2]1[N:7]([CH:8]2[CH2:10][CH2:9]2)[C:6](=[O:11])[NH:5][C:4](=[O:12])[CH:3]=1.Cl.[N:14]([O-])=[O:15].[Na+]>O>[NH2:1][C:2]1[N:7]([CH:8]2[CH2:10][CH2:9]2)[C:6](=[O:11])[NH:5][C:4](=[O:12])[C:3]=1[N:14]=[O:15]참가 물질
5
실험 절차
31.7 g (0.19 mol) of 6-amino-1-cyclopropyl-2,4-(1H,3H)-pyrimidinedione (II) was suspended in 250 ml water. To this was added 45 ml of 5N HCl and 15 g of NaNO2 (0.22 mol) which was dissolved in water. The reaction mixture was stirring for 2 hours and after cooling, the red crystals were filtered off and washed with water. Yield 31.9 g (86%) (III) NMR.
후처리
- temperatureafter cooling
- filtrationthe red crystals were filtered off
- washwashed with water
출처 및 근거
- ORD 기록
- ord-f7e9c70b647942d991d17c00b7db5480
- 출처 데이터셋
- uspto-grants-1987_02
- 특허 번호
- US04644001
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