Ethanol → Dazoquinast

HRID 236319노트

반응식

HRID 236319 반응식
[OH-].[Na+].[CH:3]1[N:7]2[C:8]3[C:13]([N:14]=[CH:15][C:6]2=[N:5][C:4]=1[C:16]([O:18]CC)=[O:17])=[CH:12][CH:11]=[CH:10][CH:9]=3.C(O)C>O>[CH:3]1[N:7]2[C:8]3[C:13]([N:14]=[CH:15][C:6]2=[N:5][C:4]=1[C:16]([OH:18])=[O:17])=[CH:12][CH:11]=[CH:10][CH:9]=3

참가 물질

5

반응물 3

HCID 702EthanolHCID 14798Sodium HydroxideHCID 13228325Ethyl imidazo[1,2-a]quinoxaline-2-carboxylate

생성물 1

HCID 71146Dazoquinast수율 107.8%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

10 ml of 1N sodium hydroxide solution were added to a suspension of 0.63 g of ethyl imidazo-[1,2-a]-quinoxaline-2-carboxylate, 10 ml of ethanol and 30 ml of water and the mixture was refluxed for one hour. The ethanol was evaporated under reduced pressure from the resulting clear yellow solution and the aqueous phase was acidified with concentrated hydrochloric acid. The mixture was filtered to obtain 0.6 g of imidazo-[1,2-a]-quinoxaline-2-carboxylic acid in the form of a buff crystalline solid melting at 274°-275° C.

후처리

  1. temperaturethe mixture was refluxed for one hour
  2. customThe ethanol was evaporated under reduced pressure from the resulting clear yellow solution
  3. filtrationThe mixture was filtered

출처 및 근거

ORD 기록
ord-e13a3de72d294beabe5c5d2727d101b0
출처 데이터셋
uspto-grants-1987_02
특허 번호
US04644002

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