Hydrochloric Acid → HCID 13770520, 화합물

HRID 236355노트

반응식

HRID 236355 반응식
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]([CH:12]1[C:20]2[C:15](=[CH:16][CH:17]=[C:18]([C:21]3([CH3:26])OCC[O:22]3)[CH:19]=2)[N:14]([CH2:27][CH3:28])[C:13]1=[O:29])=[O:11].O1CCCC1.Cl>O>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]([CH:12]1[C:20]2[C:15](=[CH:16][CH:17]=[C:18]([C:21](=[O:22])[CH3:26])[CH:19]=2)[N:14]([CH2:27][CH3:28])[C:13]1=[O:29])=[O:11]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 8028TetrahydrofuranHCID 13770519HCID 13770519, 화합물

생성물 1

HCID 13770520HCID 13770520, 화합물수율 73%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

N-(2,4-Difluorophenyl)-1-ethyl-5-(2-methyl-4,5-dihydro-1,3-dioxol-2-yl)oxindole-3-carboxamide (636 mg., 1.58 mmoles) was dissolved in 15 ml. of tetrahydrofuran to which was added 10 ml. of 1N hydrochloric acid. The solution was stirred for one hour followed by the addition of an equal volume of water. The resulting precipitate was filtered, vacuum dried and recrystallized from diisopropyl ether--methylene chloride, 412 mg. (73% yield), m.p. 160°-161° C.

후처리

  1. filtrationThe resulting precipitate was filtered
  2. customvacuum dried
  3. customrecrystallized from diisopropyl ether

출처 및 근거

ORD 기록
ord-98f5d522817049fe87974001a98463a3
출처 데이터셋
uspto-grants-1987_02
특허 번호
US04644005

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