Hydrochloric Acid → 2-Nitro-4-benzoylphenylacetic acid
반응식
[N+:1]([C:4]1[CH:9]=[C:8]([C:10](=[O:17])[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:7]=[CH:6][C:5]=1[CH:18](C(OCC)=O)[C:19]([O:21]CC)=[O:20])([O-:3])=[O:2].Cl>O1CCOCC1>[N+:1]([C:4]1[CH:9]=[C:8]([C:10](=[O:17])[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:7]=[CH:6][C:5]=1[CH2:18][C:19]([OH:21])=[O:20])([O-:3])=[O:2]참가 물질
4
실험 절차
A mixture of 14 g. (36.3 mmoles) of diethyl 2-nitro-4-benzoylphenylmalonate, 300 ml. of 4N hydrochloric acid and 300 ml. of dioxane was heated to reflux for 10 hours. The reaction mixture was concentrated in vacuo and the crude product was triturated with hot methylene chloride, 9.88 g. (95% yield), m.p. 168°-170° C.
후처리
- additionA mixture of 14 g
- temperatureto reflux for 10 hours
- concentrationThe reaction mixture was concentrated in vacuo
- customthe crude product was triturated with hot methylene chloride, 9.88 g
출처 및 근거
- ORD 기록
- ord-d19d22f9d8d14e5bb46699305da9114a
- 출처 데이터셋
- uspto-grants-1987_02
- 특허 번호
- US04644005
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