Hydrochloric Acid → 2-Nitro-4-benzoylphenylacetic acid

HRID 236370

반응식

HRID 236370 반응식
[N+:1]([C:4]1[CH:9]=[C:8]([C:10](=[O:17])[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:7]=[CH:6][C:5]=1[CH:18](C(OCC)=O)[C:19]([O:21]CC)=[O:20])([O-:3])=[O:2].Cl>O1CCOCC1>[N+:1]([C:4]1[CH:9]=[C:8]([C:10](=[O:17])[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:7]=[CH:6][C:5]=1[CH2:18][C:19]([OH:21])=[O:20])([O-:3])=[O:2]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 13408230Diethyl 2-nitro-4-benzoylphenylmalonate

생성물 1

HCID 137705362-Nitro-4-benzoylphenylacetic acid수율 95%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

A mixture of 14 g. (36.3 mmoles) of diethyl 2-nitro-4-benzoylphenylmalonate, 300 ml. of 4N hydrochloric acid and 300 ml. of dioxane was heated to reflux for 10 hours. The reaction mixture was concentrated in vacuo and the crude product was triturated with hot methylene chloride, 9.88 g. (95% yield), m.p. 168°-170° C.

후처리

  1. additionA mixture of 14 g
  2. temperatureto reflux for 10 hours
  3. concentrationThe reaction mixture was concentrated in vacuo
  4. customthe crude product was triturated with hot methylene chloride, 9.88 g

출처 및 근거

ORD 기록
ord-d19d22f9d8d14e5bb46699305da9114a
출처 데이터셋
uspto-grants-1987_02
특허 번호
US04644005

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