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Hydrochloric Acid → 3-(Butylamino)-5-(pyridin-4-yl)thiophene-2-carboxylic acid

HRID 2363952
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인쇄 미리보기

반응식

HRID 2363952 반응식
[CH2:1]([NH:5][C:6]1[CH:10]=[C:9]([C:11]2[CH:16]=[CH:15][N:14]=[CH:13][CH:12]=2)[S:8][C:7]=1[C:17]([O:19]C)=[O:18])[CH2:2][CH2:3][CH3:4].C[O-].[Na+].CO.Cl>O>[CH2:1]([NH:5][C:6]1[CH:10]=[C:9]([C:11]2[CH:16]=[CH:15][N:14]=[CH:13][CH:12]=2)[S:8][C:7]=1[C:17]([OH:19])=[O:18])[CH2:2][CH2:3][CH3:4]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 10942334Sodium MethoxideHCID 66743415Methyl 3-(butylamino)-5-(pyridin-4-yl)thiophene-2-carboxylate

생성물 1

HCID 667438043-(Butylamino)-5-(pyridin-4-yl)thiophene-2-carboxylic acid수율 85%

시약·촉매·용매 1

HCID 962
Water
용매

실험 절차

A mixture of methyl 3-(butylamino)-5-(pyridin-4-yl)thiophene-2-carboxylate (0.460 g, 1.58 mmol), sodium methoxide (0.257 g, 4.75 mmol), methanol (6.4 mL) and water (1.6 mL) was refluxed overnight. The mixture was cooled in an ice-bath and conc. HCl (0.390 mL, 4.75 mmol) was added. The resultant yellow precipitate was collected by filtration and washed with water and methanol to afford the title compound (0.370 g, 85%) as a yellow solid:

후처리

  1. temperaturewas refluxed overnight
  2. temperatureThe mixture was cooled in an ice-bath
  3. filtrationThe resultant yellow precipitate was collected by filtration
  4. washwashed with water and methanol

출처 및 근거

ORD 기록
ord-992f41a196e842cca866dfdd865bbef6
출처 데이터셋
uspto-grants-2014_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08691828B2

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