홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Sodium Bicarbonate → N-(4-Chlorobenzyl)-2-{[[2-(5-cyanothien-2-yl)-2-hydroxyethyl](methyl)amino]methyl}-3-(hydroxymethyl)-4-methyl-7-oxo-4,7-dihydrothieno[3,2-b]pyridine-6-carboxamide

HRID 23645
노트
인쇄 미리보기

반응식

HRID 23645 반응식
[Cl:1][C:2]1[CH:43]=[CH:42][C:5]([CH2:6][NH:7][C:8]([C:10]2[C:11](=[O:41])[C:12]3[S:19][C:18]([CH2:20][N:21]([CH2:23][CH:24]([C:26]4[S:27][C:28]([C:31]#[N:32])=[CH:29][CH:30]=4)[OH:25])[CH3:22])=[C:17]([CH2:33][O:34]CC[Si](C)(C)C)[C:13]=3[N:14]([CH3:16])[CH:15]=2)=[O:9])=[CH:4][CH:3]=1.C([O-])(O)=O.[Na+]>C(O)(C(F)(F)F)=O.C(Cl)Cl.C(Cl)(Cl)Cl>[Cl:1][C:2]1[CH:43]=[CH:42][C:5]([CH2:6][NH:7][C:8]([C:10]2[C:11](=[O:41])[C:12]3[S:19][C:18]([CH2:20][N:21]([CH2:23][CH:24]([C:26]4[S:27][C:28]([C:31]#[N:32])=[CH:29][CH:30]=4)[OH:25])[CH3:22])=[C:17]([CH2:33][OH:34])[C:13]=3[N:14]([CH3:16])[CH:15]=2)=[O:9])=[CH:4][CH:3]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 2

HCID 516892Sodium BicarbonateHCID 22574299N-(4-chlorobenzyl)-2-{[[2-(5-cyanothien-2-yl)-2-hydroxyethyl](methyl)amino]methyl}-4-methyl-7-oxo-3-{[2-(trimethylsilyl)ethoxy]methyl}-4,7-dihydrothieno[3,2-b]pyridine-6-carboxamide

생성물 1

HCID 22574405N-(4-Chlorobenzyl)-2-{[[2-(5-cyanothien-2-yl)-2-hydroxyethyl](methyl)amino]methyl}-3-(hydroxymethyl)-4-methyl-7-oxo-4,7-dihydrothieno[3,2-b]pyridine-6-carboxamide수율 101.3%

시약·촉매·용매 3

HCID 6212
Chloroform
용매
HCID 6344Dichloromethane용매
HCID 6422Trifluoroacetic acid용매

실험 절차

A solution of 170 mg of N-(4-chlorobenzyl)-2-{[[2-(5-cyanothien-2-yl)-2-hydroxyethyl](methyl)amino]methyl}-4-methyl-7-oxo-3-{[2-(trimethylsilyl)ethoxy]methyl}-4,7-dihydrothieno[3,2-b]pyridine-6-carboxamide in 3 mL of 75% TFA in CH2Cl2 is stirred at room temperature for 4 h, then diluted with CHCl3 and added to stirred aq. NaHCO3. The aqueous phase is extracted with 4 portions of CH2Cl2, and the combined organic phases dried (Na2SO4) and concentrated under reduced pressure. Flash chromatography of the residue on silica gel using 5% MeOH in CH2Cl2 provides 146 mg of the title compound as a white solid. Recrystallization from acetonitrile affords white needles.

후처리

  1. additionadded
  2. extractionThe aqueous phase is extracted with 4 portions of CH2Cl2
  3. dry with materialthe combined organic phases dried (Na2SO4)
  4. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-8f50fb83fb5d4f8f8d2a16e1209db090
출처 데이터셋
uspto-grants-2005_02
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06852731B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트