Acetic Anhydride → (3-Methylpyridin-4-yl)methyl acetate
반응식
[N+:1]1([O-])[CH:6]=[CH:5][C:4]([CH3:7])=[C:3]([CH3:8])[CH:2]=1.[C:10]([O:13]C(=O)C)(=[O:12])[CH3:11]>O>[C:10]([O:13][CH2:7][C:4]1[CH:5]=[CH:6][N:1]=[CH:2][C:3]=1[CH3:8])(=[O:12])[CH3:11]참가 물질
4
실험 절차
The N-oxide was added portionwise to 60 mL of acetic anhydride and the resulting dark orange solution was heated (water-bath) at about 90° C. for 1 h. The excess acetic anhydride was then distilled off under reduced pressure and the material boiling at 90°-120° C./0.1 torr (39.0 g) was collected. Chromatography of this oil (silica gel/ethyl acetate-pet.ether=2:3) afforded pure 4-acetoxymethyl-3-methylpyridine (19.0 g, 30%) as an oil: ir (neat) 1745 cm-1.
후처리
- distillationThe excess acetic anhydride was then distilled off under reduced pressure
- customthe material boiling at 90°-120° C./0.1 torr (39.0 g) was collected
출처 및 근거
- ORD 기록
- ord-4733ba85c7be43ba8ce4561e8017e9af
- 출처 데이터셋
- uspto-grants-1987_02
- 특허 번호
- US04644061
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