Water → 4-(3-(1-(7-Chloro-6-fluoroquinazolin-2-yl)azetidin-3-yl)pyrazin-2-yl)-2-fluoro-N-methylbenzamide

반응식

Cl[C:2]1[N:11]=[CH:10][C:9]2[C:4](=[CH:5][C:6]([Cl:13])=[C:7]([F:12])[CH:8]=2)[N:3]=1.FC(F)(F)C(O)=O.FC(F)(F)C(O)=O.FC(F)(F)C(O)=O.[NH:35]1[CH2:38][CH:37]([C:39]2[C:40]([C:45]3[CH:54]=[CH:53][C:48]([C:49]([NH:51][CH3:52])=[O:50])=[C:47]([F:55])[CH:46]=3)=[N:41][CH:42]=[CH:43][N:44]=2)[CH2:36]1.C(=O)([O-])[O-].[K+].[K+].O>CS(C)=O>[Cl:13][C:6]1[CH:5]=[C:4]2[C:9]([CH:10]=[N:11][C:2]([N:35]3[CH2:36][CH:37]([C:39]4[C:40]([C:45]5[CH:54]=[CH:53][C:48]([C:49]([NH:51][CH3:52])=[O:50])=[C:47]([F:55])[CH:46]=5)=[N:41][CH:42]=[CH:43][N:44]=4)[CH2:38]3)=[N:3]2)=[CH:8][C:7]=1[F:12]