Hydrochloric Acid → Tert-butyl Piperazine-1-carboxylate Hydrochloride

HRID 2365176

반응식

HRID 2365176 반응식
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[ClH:14]>ClCCl.CO>[ClH:14].[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 143452tert-Butyl piperazine-1-carboxylate

생성물 1

HCID 2755973Tert-butyl Piperazine-1-carboxylate Hydrochloride

시약·촉매·용매 2

HCID 887Methanol용매HCID 6344Dichloromethane용매

실험 절차

To a solution of tert-butyl-1-piperazinecarboxylate (15.0 g) in dichloromethane (150 mL) and methanol (150 ml) at 0° C. was added hydrogen chloride (40 mL; 2M solution in diethyl ether). The mixture was stirred at room temperature for 1.5 hours and reduced in vacuo to yield tert-butyl-1-piperazinecarboxylate hydrochloride (17.9 g).

출처 및 근거

ORD 기록
ord-cbaa2e69289a45d9a478a9adccf6d32e
출처 데이터셋
uspto-grants-2014_04
특허 번호
US08697693B2

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