Hydrochloric Acid → Benzonitrile, 4-isothiocyanato-
반응식
[C:1]([C:3]1[CH:9]=[CH:8][C:6]([NH2:7])=[CH:5][CH:4]=1)#[N:2].Cl.[C:11](Cl)(Cl)=[S:12]>O>[C:1]([C:3]1[CH:9]=[CH:8][C:6]([N:7]=[C:11]=[S:12])=[CH:5][CH:4]=1)#[N:2]참가 물질
5
실험 절차
A solution of 6 g (0.051 mol) of 4-cyanoaniline in 50 cm3 of N hydrochloric acid is poured drop by drop into a suspension of 6.5 g (0.056 mol) of thiophosgene in 100 cm3 of water. The reaction medium is vigorously stirred for two hours at room temperature. The precipitate formed is filtered, washed with three fractions of 10 cm3 of water, then dried in vacuo in the presence of phosphorus pentoxide. The substance is recrystallized from a mixture of hexane and carbon tetrachloride. 7.2 g of 4-cyanophenyl isothiocyanate are obtained (yield 85%) of which the melting point is 117°-118° C.
후처리
- customThe precipitate formed
- filtrationis filtered
- washwashed with three fractions of 10 cm3 of water
- dry with materialdried in vacuo in the presence of phosphorus pentoxide
- customThe substance is recrystallized from a mixture of hexane and carbon tetrachloride
출처 및 근거
- ORD 기록
- ord-407b0f0dcdc64bb782015053e106d906
- 출처 데이터셋
- uspto-grants-1987_02
- 특허 번호
- US04645678
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