Hydrochloric Acid → (6-Aminopyrimidin-4-yl)methanol
반응식
Cl.C(OC(=O)[NH:8][C:9]1[CH:14]=[C:13]([CH2:15][OH:16])[N:12]=[CH:11][N:10]=1)(C)(C)C>CO>[NH2:8][C:9]1[N:10]=[CH:11][N:12]=[C:13]([CH2:15][OH:16])[CH:14]=1참가 물질
4
반응 조건
- 온도
- 25 °C
실험 절차
Concentrated hydrochloric acid (0.80 mL) was added to a solution of tert-butyl-6-(hydroxymethyl)pyrimidin-4-ylcarbamate (0.50 g, 2.2 mmol) in MeOH (10 mL). The reaction was stirred at 25° C. for 1 hour and then concentrated under reduced pressure to give the desired compound (0.50 g) as a pale yellow solid, which was used in the next step without further purification. LCMS (ESI) m/z: 126.0 [M+H+].
후처리
- concentrationconcentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-4ee2171d8ce14c84bfb1b34a2b61bd25
- 출처 데이터셋
- uspto-grants-2014_04
- 특허 번호
- US08697708B2
반응 노트
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