Hydrochloric Acid → Methyl 2-amino-5-chlorobenzoate

HRID 236620

반응식

HRID 236620 반응식
[ClH:1].[NH2:2][C:3]1[CH:11]=[C:10](Cl)[CH:9]=[CH:8][C:4]=1[C:5]([OH:7])=[O:6].[C:13](=O)([O-])[O-].[Na+].[Na+]>CO.O>[NH2:2][C:3]1[CH:11]=[CH:10][C:9]([Cl:1])=[CH:8][C:4]=1[C:5]([O:7][CH3:13])=[O:6]

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 10340Sodium CarbonateHCID 666462-Amino-4-chlorobenzoic acid

생성물 1

HCID 78878Methyl 2-amino-5-chlorobenzoate수율 57.3%

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

A solution of hydrogen chloride (27.1 g) in methanol (192.2 g) is stirred at room temperature and 2-amino-4-chlorobenzoic acid (25 g) is added. The mixture is heated under reflux for 10 hours, then cooled and neutralised with a solution of sodium carbonate (20 g) in water (200 ml). The solid is filtered off, washed with water, and dried in vacuo at 65° C. to give methyl 2-amino-5-chlorobenzoate (15.5 g).

후처리

  1. temperatureThe mixture is heated
  2. temperatureunder reflux for 10 hours
  3. temperaturecooled
  4. filtrationThe solid is filtered off
  5. washwashed with water
  6. customdried in vacuo at 65° C.

출처 및 근거

ORD 기록
ord-feef69200ce947deb4605e8d75cc6675
출처 데이터셋
uspto-grants-1987_02
특허 번호
US04645818

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