Hydrochloric Acid → HCID 11965253, 화합물

HRID 2366370노트

반응식

HRID 2366370 반응식
[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6](/[C:12](=[CH:15]/[C:16]2[S:17][C:18]([N:21]3[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]3)=[CH:19][CH:20]=2)/[C:13]#[N:14])[CH:7]=[CH:8][C:9]=1[O:10][CH3:11]>>[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6](/[C:12](=[CH:15]/[C:16]2[S:17][C:18]([N:21]3[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]3)=[CH:19][CH:20]=2)/[C:13]#[N:14])[CH:7]=[CH:8][C:9]=1[O:10][CH3:11]

참가 물질

3

반응물 2

HCID 313Hydrochloric AcidHCID 11965251HCID 11965251, 화합물

생성물 1

HCID 11965253HCID 11965253, 화합물수율 94%

실험 절차

0.1N Hydrochloric acid (7.0 mL) was added to Compound 4 (226 mg), and purified water (30 mL), acetonitrile (30 mL), and chloroform (3 mL) were added to the mixture, to thereby dissolve the mixture. The solution was stirred at room temperature for 1 hour, and the solvent was evaporated to dryness. The residue was suspended in hexane-ethyl acetate, and the solvent was evaporated to dryness, followed by thoroughly drying, to thereby yield the target product (yield: 235 mg, 94%).

후처리

  1. custompurified water (30 mL), acetonitrile (30 mL), and chloroform (3 mL)
  2. additionwere added to the mixture
  3. dissolutionto thereby dissolve the mixture
  4. customthe solvent was evaporated to dryness
  5. customthe solvent was evaporated to dryness
  6. customby thoroughly drying

출처 및 근거

ORD 기록
ord-231344f792c6483a9607f331926078bf
출처 데이터셋
uspto-grants-2014_04
특허 번호
US08697742B2

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