Hydrochloric Acid → (Z)-3-[5-(3-amino-phenyl)-furan-2-yl]-2-(3,4-dimethoxy-phenyl)-acrylonitrile hydrochloride

HRID 2366378노트

반응식

HRID 2366378 반응식
[ClH:1].[NH2:2][C:3]1[CH:4]=[C:5]([C:9]2[O:13][C:12](/[CH:14]=[C:15](/[C:18]3[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[C:20]([O:26][CH3:27])[CH:19]=3)\[C:16]#[N:17])=[CH:11][CH:10]=2)[CH:6]=[CH:7][CH:8]=1>>[ClH:1].[NH2:2][C:3]1[CH:4]=[C:5]([C:9]2[O:13][C:12](/[CH:14]=[C:15](/[C:18]3[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[C:20]([O:26][CH3:27])[CH:19]=3)\[C:16]#[N:17])=[CH:11][CH:10]=2)[CH:6]=[CH:7][CH:8]=1

참가 물질

3

반응물 2

HCID 313Hydrochloric AcidHCID 11842656(Z)-3-[5-(3-amino-phenyl)-furan-2-yl]-2-(3,4-dimethoxy-phenyl)-acrylonitrile

생성물 1

HCID 67226969(Z)-3-[5-(3-amino-phenyl)-furan-2-yl]-2-(3,4-dimethoxy-phenyl)-acrylonitrile hydrochloride수율 96%

실험 절차

0.1N Hydrochloric acid (3.7 mL) was added to Compound 22 (117 mg), and purified water (30 mL), acetonitrile (30 mL), and chloroform (5 mL) were added to the mixture, to thereby dissolve the mixture. The solution was stirred at room temperature for 1 hour, and the solvent was evaporated to dryness. The residue was suspended in hexane-ethyl acetate, and the solvent was evaporated to dryness, followed by thoroughly drying, to thereby yield the target product (yield: 124 mg, 96%).

후처리

  1. custompurified water (30 mL), acetonitrile (30 mL), and chloroform (5 mL)
  2. additionwere added to the mixture
  3. dissolutionto thereby dissolve the mixture
  4. customthe solvent was evaporated to dryness
  5. customthe solvent was evaporated to dryness
  6. customby thoroughly drying

출처 및 근거

ORD 기록
ord-1aaf467c33b14aa2887449371b344046
출처 데이터셋
uspto-grants-2014_04
특허 번호
US08697742B2

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