Dimethylformamide → HCID 25194664, 화합물
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Br[C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[C:4]([N+:9]([O-:11])=[O:10])[C:3]=1[NH2:12].[CH3:13][N:14](C=O)C>[C-]#N.[Zn+2].[C-]#N.[Pd].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>[NH2:12][C:3]1[C:4]([N+:9]([O-:11])=[O:10])=[CH:5][C:6]([F:8])=[CH:7][C:2]=1[C:13]#[N:14]참가 물질
5
실험 절차
A suspension of EXAMPLE 45A (22.7 g), zinc cyanide (22.6 g) and tetrakis(triphenylphosphine) palladium (7.78 g) in anhydrous DMF (300 mL) was heated at 80° C. for 22 hours. After cooling, the reaction mixture was partitioned between ethyl acetate (500 mL) and brine (500 mL). The organic phase was washed with water and concentrated. Recrystallization of the concentrate from methanol provided EXAMPLE 45B.