HCID 68873567, 화합물 → HCID 68874499, 화합물

HRID 2366648노트

반응식

HRID 2366648 반응식
[N+:1]([C:4]1[CH:5]=[N:6][C:7]2[C:12]([C:13]=1[NH:14][CH2:15][CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:11][CH:10]=[CH:9][CH:8]=2)([O-])=O>[Pt]>[NH2:1][C:4]1[CH:5]=[N:6][C:7]2[C:12]([C:13]=1[NH:14][CH2:15][CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:11][CH:10]=[CH:9][CH:8]=2

참가 물질

3

반응물 1

HCID 68873567HCID 68873567, 화합물

생성물 1

HCID 68874499HCID 68874499, 화합물수율 94.3%

시약·촉매·용매 1

HCID 23939Platinum촉매

실험 절차

Ethyl N-(3-nitroquinolin-4-yl)-β-alaninate (50.0 g, 173 mmol) was hydrogenated in the presence of 5% platinum on carbon (1.0 g) according to the method described in Part C of Example 1. The reaction was allowed to proceed overnight under hydrogen pressure (40 psi, 2.8×105 Pa) and then subjected to the work-up procedure to provide 42.3 g of ethyl N-(3-aminoquinolin-4-yl)-β-alaninate.

출처 및 근거

ORD 기록
ord-3ee6c180a6a0497d96153896523de443
출처 데이터셋
uspto-grants-2014_04
특허 번호
US08697873B2

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