Ethyl 4,4,4-trifluoroacetoacetate → Ethyl 4,4,4-trifluoro-3-hydroxybutanoate

HRID 236668

반응식

HRID 236668 반응식
[F:1][C:2]([F:12])([F:11])[C:3](=[O:10])[CH2:4][C:5]([O:7][CH2:8][CH3:9])=[O:6]>C(OCC)(=O)C.O=[Pt]=O>[OH:10][CH:3]([C:2]([F:1])([F:11])[F:12])[CH2:4][C:5]([O:7][CH2:8][CH3:9])=[O:6]

참가 물질

4

반응물 1

HCID 67793Ethyl 4,4,4-trifluoroacetoacetate

생성물 1

HCID 136210Ethyl 4,4,4-trifluoro-3-hydroxybutanoate수율 76%

시약·촉매·용매 2

HCID 345198Adams' catalyst촉매HCID 8857Ethyl Acetate용매

실험 절차

A solution of 19.31 g of ethyl trifluoroacetoacetate (Fairfield Chemical) in 50 ml of ethyl acetate was hydrogenated at atmospheres on a Parr shaker over (0.5 g) PtO2 as a catalyst. The volatiles were removed and the residue distilled under high vacuum to afford 14.75 g (76%) of the title compound as a low melting solid. bp=47°-49° C. at 0.1 mm of Hg, mp (uncorrected)=about 25° C.

후처리

  1. customThe volatiles were removed
  2. distillationthe residue distilled under high vacuum

출처 및 근거

ORD 기록
ord-b35ebaa457464f7bb93f76e24efe9474
출처 데이터셋
uspto-grants-1987_02
특허 번호
US04645838

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