Triethylamine → HCID 69506747, 화합물

HRID 2366712노트

반응식

HRID 2366712 반응식
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][N:10]=2)[N:5]=[CH:4][C:3]=1[N+:12]([O-:14])=[O:13].Cl.[NH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][C:22]([O:24][CH2:25][CH3:26])=[O:23].C(N(CC)CC)C>C(Cl)(Cl)Cl>[N+:12]([C:3]1[CH:4]=[N:5][C:6]2[C:11]([C:2]=1[NH:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][C:22]([O:24][CH2:25][CH3:26])=[O:23])=[N:10][CH:9]=[CH:8][CH:7]=2)([O-:14])=[O:13]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 458476Ethyl 6-aminohexanoate hydrochlorideHCID 131227874-Chloro-3-nitro-1,5-naphthyridine

생성물 1

HCID 69506747HCID 69506747, 화합물

시약·촉매·용매 1

HCID 6212Chloroform용매2회

반응 조건

온도
0 °C

실험 절차

A suspension of 4-chloro-3-nitro[1,5]naphthyridine (9.0 g, 42.9 mmol) in chloroform (180 mL) was cooled to approximately 0° C. Ethyl 6-aminohexanoate hydrochloride (12.6 g, 64.4 mmol) and triethylamine (16.6 mL, 119 mmol) were sequentially added with stirring, and the reaction was stirred for 15 minutes. The mixture was diluted with chloroform (180 mL), washed with 1% aqueous sodium carbonate (3×125 mL), dried over sodium sulfate, filtered, and concentrated under reduced pressure to provide ethyl 6-(3-nitro[1,5]naphthyridin-4-ylamino)hexanoate as a yellow oil.

후처리

  1. stirringthe reaction was stirred for 15 minutes
  2. washwashed with 1% aqueous sodium carbonate (3×125 mL)
  3. dry with materialdried over sodium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-260bfe37ee4c43ff9cbfaa0af57ab2eb
출처 데이터셋
uspto-grants-2014_04
특허 번호
US08697873B2

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