Hydrochloric Acid → HCID 178477956, 화합물

HRID 2367337노트

반응식

HRID 2367337 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[C:10]([CH:13]3[O:18][CH2:17][CH2:16][N:15](CC4C=CC=CC=4)[CH2:14]3)[NH:11][CH:12]=2)=[CH:4][CH:3]=1.Cl>C(O)C.[Pd]>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[C:10]([CH:13]3[O:18][CH2:17][CH2:16][NH:15][CH2:14]3)[NH:11][CH:12]=2)=[CH:4][CH:3]=1

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 1784779552-[4-(4-Chlorophenyl)-1H-imidazol-2-yl]-4-(phenylmethyl)morpholine

생성물 1

HCID 178477956HCID 178477956, 화합물수율 139%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

2-[4-(4-Chlorophenyl)-1H-imidazol-2-yl]-4-(phenylmethyl)morpholine (2.8 g, 7.91 mmol) was hydrogenated in ethanol (30 mL) over of Pd/C (10 wt %, 0.842 g, 0.791 mmol). To the mixture 0.2 mL of concentrated hydrochloric acid was added. After stirred at room temperature overnight, the catalyst was filtered off. The filtrate was concentrated to get 2.9 g of residue, which was purified by preparative HPLC to afford the title compound (200 mg) as a pale solid. LC-MS (ES) m/z=264 [M+H]+.

후처리

  1. filtrationthe catalyst was filtered off
  2. concentrationThe filtrate was concentrated

출처 및 근거

ORD 기록
ord-cc4ed663ce224a338ea6082eea4c08c9
출처 데이터셋
uspto-grants-2014_04
특허 번호
US08697685B2

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