Hydrochloric Acid → 2-(2-Morpholinyl)-4,5,6,7-tetrahydro-1H-benzimidazole

HRID 2367344노트

반응식

HRID 2367344 반응식
C1(C[N:8]2[CH2:13][CH2:12][O:11][CH:10]([C:14]3[NH:18][C:17]4[CH2:19][CH2:20][CH2:21][CH2:22][C:16]=4[N:15]=3)[CH2:9]2)C=CC=CC=1.Cl>C(O)C.[Pd]>[NH:8]1[CH2:13][CH2:12][O:11][CH:10]([C:14]2[NH:15][C:16]3[CH2:22][CH2:21][CH2:20][CH2:19][C:17]=3[N:18]=2)[CH2:9]1

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 585048062-[4-(Phenylmethyl)-2-morpholinyl]-4,5,6,7-tetrahydro-1H-benzimidazole

생성물 1

HCID 585044142-(2-Morpholinyl)-4,5,6,7-tetrahydro-1H-benzimidazole수율 147.3%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

2-[4-(Phenylmethyl)-2-morpholinyl]-4,5,6,7-tetrahydro-1H-benzimidazole (0.78 g, 2.62 mmol) was hydrogenated in ethanol (30 mL) in the presence of Pd/C (10 wt %, 0.279 g, 0.262 mmol). To the reaction mixture was added 0.2 mL of concentrated hydrochloric acid. After stirring at room temperature overnight, the catalyst was filtered off. The filtrate was concentrated to afford the title compound (0.8 g) as a yellow oil. LC-MS (ES) m/z=208 [M+H]+.

후처리

  1. filtrationthe catalyst was filtered off
  2. concentrationThe filtrate was concentrated

출처 및 근거

ORD 기록
ord-49179edbbc5e499aaebf2cf1e331f81e
출처 데이터셋
uspto-grants-2014_04
특허 번호
US08697685B2

반응 노트

불러오는 중…