1,2-Dichloroethane → HCID 58504507, 화합물

HRID 2367555노트

반응식

HRID 2367555 반응식
[CH3:1][C:2]([O:5][C:6]([N:8]1[C@H:13]([CH2:14][CH3:15])[CH2:12][O:11][C@H:10]([C:16]([OH:18])=O)[CH2:9]1)=[O:7])([CH3:4])[CH3:3].[CH:19]1([NH2:25])[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1.C1C=NC2N(O)N=NC=2C=1.C(Cl)CCl>C(Cl)Cl>[CH:19]1([NH:25][C:16]([C@H:10]2[O:11][CH2:12][C@@H:13]([CH2:14][CH3:15])[N:8]([C:6]([O:5][C:2]([CH3:1])([CH3:3])[CH3:4])=[O:7])[CH2:9]2)=[O:18])[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1

참가 물질

6

반응물 4

HCID 111,2-DichloroethaneHCID 7965CyclohexylamineHCID 181649HOAtHCID 51356009HCID 51356009, 화합물

생성물 1

HCID 58504507HCID 58504507, 화합물수율 90.2%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To (2S,5R)-4-{[(1,1-dimethylethyl)oxy]carbonyl}-5-ethyl-2-morpholinecarboxylic acid (0.250 g, 0.964 mmol) in CH2Cl2 (10 mL) were added cyclohexylamine (0.096 g, 0.964 mmol), HOAt (0.131 g, 0.964 mmol) and EDC (0.222 g, 1.157 mmol), and the reaction was stirred at room temperature overnight. The reaction mixture was washed with H2O (2×) and the organics were dried over Na2SO4 and concentrated to afford the title compound (0.296 g) as a brown oil. LC-MS (ES) m/z=241 [M+H-Boc]+.

후처리

  1. washThe reaction mixture was washed with H2O (2×)
  2. dry with materialthe organics were dried over Na2SO4
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-5ccd88d43369409ab3f8a069081adb18
출처 데이터셋
uspto-grants-2014_04
특허 번호
US08697685B2

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