1,2-Dichloroethane → HCID 58504456, 화합물

HRID 2367560노트

반응식

HRID 2367560 반응식
[CH3:1][C:2]([O:5][C:6]([N:8]1[C@H:13]([CH2:14][CH3:15])[CH2:12][O:11][C@H:10]([C:16]([OH:18])=O)[CH2:9]1)=[O:7])([CH3:4])[CH3:3].[CH2:19]([NH2:26])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.C1C=NC2N(O)N=NC=2C=1.C(Cl)CCl>C(Cl)Cl>[CH2:14]([C@H:13]1[N:8]([C:6]([O:5][C:2]([CH3:1])([CH3:3])[CH3:4])=[O:7])[CH2:9][C@@H:10]([C:16]([NH:26][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[O:18])[O:11][CH2:12]1)[CH3:15]

참가 물질

6

반응물 4

HCID 111,2-DichloroethaneHCID 7504BenzylamineHCID 181649HOAtHCID 51356009HCID 51356009, 화합물

생성물 1

HCID 58504456HCID 58504456, 화합물수율 105.1%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To (2S,5R)-4-{[(1,1-dimethylethyl)oxy]carbonyl}-5-ethyl-2-morpholinecarboxylic acid (0.390 g, 1.504 mmol) in CH2Cl2 (10 mL) were added benzylamine (0.164 mL, 1.504 mmol), HOAt (0.205 g, 1.504 mmol) and EDC (0.346 g, 1.805 mmol). The reaction was stirred at room temperature overnight. The reaction mixture was washed with H2O (3×) and the organics were then dried over Na2SO4 and concentrated to afford the title compound (0.551 g). LC-MS (ES) m/z=249 [M+H-Boc]+.

후처리

  1. washThe reaction mixture was washed with H2O (3×)
  2. dry with materialthe organics were then dried over Na2SO4
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-2ebf1f1c9bde4752a8961ca534832551
출처 데이터셋
uspto-grants-2014_04
특허 번호
US08697685B2

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