Triethylamine → N-(2-Benzyl-5-phenyl-2H-pyrazol-3-yl)-2-[3-(2-chloro-phenyl)-ureido]-2-methyl-propionamide

참여 물질

역할	이름	HCID	투입량
반응물	Triethylamine	HCID 8471	—
반응물	Chlorophenyl isocyanate	HCID 76833	—
반응물	1-benzyl-3-phenyl-1H-pyrazol-5-amine	HCID 684746	—
반응물	2-Amino-2-methylpropanoyl chloride hydrochloride	HCID 21415505	—
용매	Dichloromethane	HCID 6344	—
생성물	N-(2-Benzyl-5-phenyl-2H-pyrazol-3-yl)-2-[3-(2-chloro-phenyl)-ureido]-2-methyl-propionamide	HCID 44612210	—

반응 단계

2-Amino-2-methyl-propionyl chloride hydrochloride (150 mg, 1.2 mmol) and 2-benzyl-5-phenyl-2H-pyrazol-3-ylamine (200 mg, 0.8 mmol) were stirred in DCM (5 mL) containing triethyl amine (100 μL, 0.8 mmol). After two hours, 2-chlorophenyl isocyanate (220 mg, 0.9 mmol) and triethyl amine (100 μL, 0.8 mmol) were added. Purification by silica gel chromatography gave the title compound. 1H NMR (400 MHz, DMSO-D6) δ 1.44 (s, 6H) 5.23 (s, 2H) 6.54 (s, 1H) 6.92 (s, 1H) 7.17 (s, 4H) 7.24 (s, 3H) 7.36 (s, 3H) 7.55 (s, 1H) 7.74 (s, 2H) 8.04 (s, 1H) 8.15 (s, 1H) 9.81 (s, 1H). m/z 488.0 (MH+).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08703761B2
출처 데이터셋	uspto-grants-2014_04
ORD ID	ord-b33869031f744952a7fe03b62e836fb4
출처 메모	uspto-grants-2014_04